Many types of localized reactive lesions may occur on the gingiva, including focal fi brous hyperplasia, pyogenic granuloma, peripheral giant cell granuloma and peripheral ossifying fi broma (POF). Clinically differentiating one from the other as a specific entity is often not possible. Histopathological examination is needed in order to positively identify the lesion. The POF is one such lesion, which is a reactive gingival overgrowth occurring frequently in the maxillary anterior region in teenagers and young adults. They are pink to red in color, and commonly associated with poor oral hygiene and early periodontal disease. We report in this study, the clinical report of a 12 year-old male patient with a POF in the maxilla associated with actinomycosis infection. Based on the clinical and histopathological evaluations, the diagnosis was concluded as POF. Clinical, radiographical and histological characteristics are discussed and recommendations regarding treatment and follow-up are provided.