Pediatric dentistry has been associated with lots of fear and anxiety shown by children toward dental personnel and to dental procedures. Therefore, the stress factor is high in children visiting dentists, and this stress may increase or decrease in the subsequent visits that follow dependent on to what they are exposed to during these visits, especially treatments like pulp therapies. This study was designed to evaluate the salivary cortisol levels in children undergoing endodontic treatment. The salivary cortisol levels were investigated in 60 children who were divided into two groups: one study group and one control group. Pulp therapies were performed on the study group in four scheduled appointments. The control group was not subjected to any procedure. Saliva samples were collected from both the groups. Salivary cortisol levels were evaluated using the Salivary Cortisol Enzyme Immunoassay Kit. The results indicated that the salivary cortisol levels increased in the study group when compared with the children in the control group (P < 0.001). The study concludes that the salivary cortisol levels increased in children who were subjected to endodontic treatment when compared with the children who were not subjected to any such procedures.