Ibuprofen is a commonly used over-the counter drug for the treatment of fever, headache, joint pain, migraine, and other mild inflammatory conditions. It is available alone or in combination with various other drugs. Various drug reactions associated with non-steroidal anti-inflammatory drugs (NSAIDs) are rashes, gastrointestinal ulcers, hepatic toxicity, acute exacerbation of asthma, Stevens-Johnson syndrome, respiratory skin rashes and anaphylaxis. Though the hypersensitivity reactions to NSAIDs are not rare but remain unnoticed and undiagnosed, especially in children. This case report highlights the oral rehabilitation in a rare case of ibuprofen induced hypersensitivity reaction, which manifested as Stevens Johnson reaction in a young female child.