2Department of Conservative Dentistry and Endodontics, Amrita School of Dentistry, Amrita Vishwa Vidyapeetham, Kerala, India
Demineralization begins as a reversible process and current trends have surpassed the conventional options of invasive treatment to a more targeted non-invasive early management of reversible lesions using various new non fluoride agents. Casein phosphopeptide-amorphous calcium phosphate is one such non-fluoride agent introduced with the potential of early remineralization in dental caries and dental erosion and to overcome conditions of dentine hypersensitivity. Various modifications of the agent have further expanded its applications in the dental field. This review was therefore, compiled from a final of 70 fulltext articles searched on PubMed and Google Scholar that had the specified MeSH terms, published in English from the year 2000-2020, to present an update on the innumerable applications and modifications of this agent in pediatric dental practice.